stream It is also known as 2-butanone (USEPA, 1999), methyl acetone, ethyl methyl ketone, and methyl propanone. Methyl Ethyl Ketone CAS RN: 78-93-3 Health Effects. Get the latest public health information from CDC: https://www.coronavirus.gov. Publication Date: 1989: Page Count: 42: Abstract: The report summarizes and evaluates information relevant to a preliminary interim assessment of adverse health effects associated with specific chemicals or compounds. However, in most cases, recovery is usually rapid without sequelae. 3) INGESTION: Oral irritation, nausea, vomiting, and metabolic acidosis may occur. endobj endstream 2,5-Hexanedione has an effect on spermatogenesis in male experimental animals. Human data is lacking. Subjects were tested for neurobehavioral performance in an environmental chamber to detect the presence of subclinical central nervous system effects from 4-hr exposures to methyl isobutyl ketone (MIBK) at 100 ppm, methyl ethyl ketone (MEK) at 200 ppm, MIBK at 50 ppm with MEK at 100 ppm, or a placebo (i.e., a 5-min presentation of 25 ppm MEK-MIBK at each exposure period outset). Prepared by the Office of Health and Environ- mental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. An interaction occurred between gender and alcohol ingestion, such that more statistically significant performance decrements were found for females than for males. x��Zے��}�W�C⒪(3�R�Jj�R,EVY��QU�yCYC��~�_�rz ��ʲ��K�����ݧ{F��?r� ����w7���[:�벛5{y���������yD��?��k�p��a�9��Y/���M�x{���u�'������+�e���B�\�T�l]�������g���9��N��*�R�N�u��x�B%O����q���]�=�����=���i�:��c����v%gﭽz������ѿ��\�����9n�_�{!�T���XV����s���|�j](v����7�O�:��Y Alcohol ingestion, however, produced significant decrements on every performance test except memory scanning and mood. Significant odor sensations and irritant effects were reported by the subjects during the chemical exposures. Dick RB(1), Krieg EF Jr, Setzer J, Taylor B. KETONE PEROXIDES are highly reactive and corrosive, and are discussed in a separate document. B) TOXICOLOGY: Ketones cover a wide range of substances. stream Ethanol by ingestion (95%-0.84 ml/kg) was used as a positive control. Several hundred calls are made annually to poison centers, but very few have any major effects. NLM 3 0 obj The principal effects resulting from exposures to MEK and MIBK at the durations and concentrations used in the study are limited to sensory and irritant effects. <> Safety assessment of MIBK (methyl isobutyl ketone). Additionally, chemical measurements (blood and breath) and reports of sensory and irritant effects were measured. USA.gov. COVID-19 is an emerging, rapidly evolving situation. Chronic exposures to six-carbon, linear chain ketones (methyl-n-butyl ketone, 2,5-hexanedione) metabolized to gamma-diketones are implicated in axonal neuropathy with secondary myelin damage. 0.2.1 SUMMARY OF EXPOSURE. They are a natural by-product of fatty acid metabolism and have industrial uses as solvents, polymer precursors and in pharmaceuticals. Dick RB, Brown WD, Setzer JV, Taylor BJ, Shukla R. Toxicol Lett. Effects of short duration exposures to acetone and methyl ethyl ketone. It is characterised as a colourless liquid that has a … | Health Effects Assessment for Methyl Ethyl Ketone. 2) OCULAR: Splash exposures of ketones to the eyes may cause varying degrees of irritation, depending on the ketone. The neurotoxic effects of acetone, methyl ethyl ketone (MEK), and cyclohexanone on Romanian workers and the impact of those effects on industry environmental standards have been controversial subjects. Health Effects Assessment for Methyl Ethyl Ketone. Environ Health Perspect. "�����^����:�{ĂWK�s�.雷�]&�Ѕ0��@{j·z��x��d�4Mq�JȬ1/�s�k��U��M���0߯AQ~�q�8C�cm��'XOi ��p�[��yr���DG��E�͛��C=ŶL���g�iQ�˟�>5�� 2004;23 Suppl 1:29-57. doi: 10.1080/10915810490274298. Clipboard, Search History, and several other advanced features are temporarily unavailable. HAZARDS IDENTIFICATION This material is considered to be hazardous according to regulat ory guidelines (see MSDS Section 15). Author information: (1)Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226. | A) USES: Ketones are organic compounds with a carbonyl group attached to a carbon atom. A) Limited studies have generally documented little or no effect of ketones on reproduction in experimental animals. | Neurobehavioral effects from acute exposures to methyl isobutyl ketone and methyl ethyl ketone. FK����F�USouy���}�|�٣q9'�>�z���.|�?�cυC��N+C��(���. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. <> Kawai T, Zhang ZW, Takeuchi A, Miyama Y, Sakamoto K, Higashikawa K, Ikeda M. Int Arch Occup Environ Health. Health Effects. endobj A) No adequate human studies exist for the agents in this category. Some symptoms reported include mucous membrane irritation, nausea, vomiting, headache, vertigo, incoordination, CNS depression, and cardiorespiratory failure. Methyl ethyl ketone is configured as CH3COC2H5 or C4H8O (CEPA, 1999) (Illustrations 1 & 2, Wikipedia, 2011). <> 6 0 obj They are a natural by-product of fatty acid metabolism and have industrial uses as solvents, polymer precursors and in pharmaceuticals. 1988 Oct;43(1-3):31-49. doi: 10.1016/0378-4274(88)90019-7. Print. The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. The chemical exposures produced statistically significant performance effects on only 4 of 32 measures (% correct responses-visual vigilance, movement time-CRT, SRT, % incorrect responses-dual task). Int J Toxicol. 2003 Feb;76(1):17-23. doi: 10.1007/s00420-002-0374-9. Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products. The use of the Truven Health Analytics Inc. products is at your sole risk. �D �yw��1�gU��s疽Ng�^��y��4�`� ��;۔�+ϟλrZj�����W:� �l��IЪ[T�*`�������K�*E�1��M���2L$��`���bml��e>E.�.B?=TP�pkV�]8����6���e�:X�n�Rh�������f��(U�Õ nކ�]�= In part 1, the number of studies between the years 2000 to 2010 that have investigated the health effects of each chemical in specific medical categories Please enable it to take advantage of the complete set of features! Health and Environmental Effects Profile for Methyl Ethyl Ketone. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 1) INHALATION: Acute inhalation of ketones may cause varying effects, depending on the extent and duration of exposure. x��V]o�F}�W��D"�|S�U �&�%���>4U� x�=�=����چ`�4�Y�~�cϙs��{9|lQ���V�_0F(�0y��I�����xρ����`�7��O�2�&��WS89O].\_���p@)����ũ�gL��&_�9��*C��, �M[���L1A�J���r�cl�għ�:�.l���:�������D{��B�K"�|�Y�x�b˪[ �V�F�K�+Jk���B�+��� ��Ԯ2�27�,�o�����������/{!��bJզn�Q^��|`��dK�L�d�+7�i��M"2����)�q��0��x�٤�G��(����6��M8�;����L��s�ĥ� }�J[����ɤY�68�8�~��ig�p�!Nm�"��z�VDp��7^=đs? endobj Some studies report positive findings, but this category of agents appears to be generally non-mutagenic or only weakly mutagenic. Epub 2002 Sep 18. Find more information on this substance at: A) USES: Ketones are organic compounds with a carbonyl group attached to a carbon atom. Gas concentrations are in percent by volume. Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. Additionally, the MIBK-MEK combination exposure showed no evidence of any interaction effects on either the behavioral or chemical measurements. Contact urticaria has also been reported. 4) DERMAL: Skin exposures to ketones in liquid or vapor form may result in dermatitis and paresthesias of the affected areas. %PDF-1.5 This study reviewed the health effects of toluene, benzene, methyl ethyl ketone peroxide (MEKP) and epichlorohydrin (ECH). METHYL ETHYL KETONE 78 -93 -3 100% * All concentrations are percent by weight unless material is a g as. There is no underlying common mechanism in which they exert toxic effects, though some have irritant properties. �H]���>��b�j�� X� �ڑ�k�y�[�RJ�f��{����5��=���.`����J����)o'�F�o� S Br J Ind Med. A) Extremely limited data are available for this class of agents. ���+���|�/��]������U缆��V0�>�F=�R�Ay(�L���d%5s���ߟx�������D���)��u�6D�IR� =�U���x_ H8� POTENTIAL PHYSICAL / CHEMICAL EFFECTS Flammable. 3. These effects, however, were not substantial and could not be attributed directly to the chemical exposures. Exposure of rats to methyl ethyl ketone at a level of 200 ppm, 12 hours/ day, 7 days/week for 24 weeks resulted 1n slight neurological effects visible only at 4 months of treatment (Takeuchl et al., 1983), but exposure of rats to 1125 ppm continuously for 5 months did not result In neuropathy, defined 1n terms of paralysis (Salda et al., 1976). The MEK results agree with earlier MEK experiments at comparable exposure conditions, and the MIBK results are consistent with a recent Swedish study that used MIBK exposures and showed no significant behavioral performance decrements from single MIBK exposures at 50 ppm with 50 W exercise. 0.2.1.1 ACUTE EXPOSURE. Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. Get the latest public health information from CDC: https://www.coronavirus.govGet the latest research information from NIH: https://www.nih.gov/coronavirus, PDF documents can be viewed with the free Adobe® Reader. <> Ingestion of significant amounts of ketones may cause respiratory depression. A) Experimental animal studies are limited, but are generally negative, and agents in this group have little mutagenic activity. PB90142456. This manifests with peripheral neuropathy symptoms with paresthesias and muscle weakness. 1996 Apr;104 Suppl 2(Suppl 2):361-6. doi: 10.1289/ehp.96104s2361. NIH 5 0 obj be exposed to. Ketone vapors may cause irritation and lacrimation. Neurotoxic interactions of industrially used ketones. Pulmonary aspiration may result in a chemical pneumonitis. 0.2.1.1 ACUTE EXPOSURE. This site needs JavaScript to work properly. 4 0 obj 0.2.1 SUMMARY OF EXPOSURE. For many specific ketones, no data are available. NCI CPTC Antibody Characterization Program. C) EPIDEMIOLOGY: Acute toxicity is rare. Behavioral methods and organic solvents: questions and consequences. All treatments or procedures are intended to serve as an information resource for physicians or other competent healthcare professionals performing the consultation or evaluation of patients and must be interpreted in view of all attendant circumstances, indications and contraindications. Subjects were 68 males and 75 females recruited from local universities; ages ranged from 18 to 32 years. To scientifically substantiate the standards, a study was conducted on three groups of workers to … Get the latest research from NIH: https://www.nih.gov/coronavirus. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. HHS Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. 1989 Feb;46(2):111-21. doi: 10.1136/oem.46.2.111. Five psychomotor tests (choice reaction time [CRT], simple reaction time [SRT], visual vigilance, dual task [auditory tone discrimination and tracking], memory scanning), one sensorimotor test (postural sway), and a test of mood (profile of mood states) were used to measure neurobehavioral effects.
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