Nat Struct Mol Biol.
eCollection 2014 Aug. J Mol Biol. If you are the author of this article you still need to obtain permission to reproduce Even more exciting, when they fixed the proteins to the DNA prior to EM examination and utilized carbon films and tungsten shadow casting, trombone loops were seen for the first time. doi: 10.1371/journal.pgen.1004543. Replisomes are dynamic multiprotein machines capable of simultaneously replicating both strands of the DNA duplex. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Structures of Pol III holoenzyme components and comparison to its eukaryotic counterparts.
Replisome dynamics and use of DNA trombone loops to bypass replication blocks. They found that the lagging strand Fetching data from CrossRef. Model for skipping a lesion on the lagging strand. Get the latest public health information from CDC: https://www.coronavirus.gov. Authors contributing to RSC publications (journal articles, books or book chapters) Characterization of a triple DNA polymerase replisome. Corresponding authors, a
For example, the bacterial replisome utilizes clamps and clamp loaders to coordinate the actions required of the trombone model of lagging strand synthesis made famous by Bruce Alberts. Bruce Alberts first proposed the “trombone” DNA looping model of lagging strand DNA replication nearly thirty years ago.1DNA looping on the lagging strand is now well established in the T4 phage replication system,2and a variety of other replication systems.
Single-molecule analysis of the Escherichia coli replisome and use of clamps to bypass replication barriers. In all cases the Ref. Step 2: The clamp loader binds a primed template which enters into the central chamber of the clamp loader through the gap between δ and δ′ and the open ring.
Epub 2009 Sep 29. DNA and Chromosomes - Molecular Biophysics, DNA Replication Catalyzed by Herpes Simplex Virus Type 1 Proteins Reveals Trombone Loops at the Fork, American Society for Biochemistry and Molecular Biology. Replisomes are dynamic multiprotein machines capable of simultaneously replicating both strands of the DNA duplex. DNA Replication Catalyzed by Herpes Simplex Virus Type 1 Proteins Reveals Trombone Loops at the Fork ♦ See referenced article, J. Biol.
The details of DNA replication in the herpes simplex virus type 1, which causes cold sores, are not well understood. This observation is consistent with the trombone model of DNA replication, where the
Chem. USA.gov.
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